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The normal cooperative interactions between Spi-1, C/EBPβ and IE2 on the IL1B promoter (shown in Fig 1d) are blocked by the 291–364 fragment of IE2 because it encompasses region 315–328, which binds to Spi-1 and C/EBPβ, but lacks other transactivation elements and the DNA binding domain of IE2 (shown in Fig 1c). Half-filled ovals denote mutual interactions sites.
