Abstract
We have identified 23 334 individuals (40%) of twins born in Norway 1905–45 where both twins were alive in 1960 without malignant disease. These were linked to the Cancer Registry of Norway. A reduced risk of malignant disease was demonstrated among twins for all tumour sites combined; standardized incidence rate (SIR): 0.90 (95% CI 0.85–0.94) in females and 0.95 (95% Cl 0.90–0.99) in males. In both sexes, we observed a significant reduced incidence of malignant melanomas of the skin. The incidence of colorectal cancer tended to be reduced for both sexes. In females, the incidence of tumours of the central nervous system and lungs were reduced. We consider our findings are real, but cannot explain them. © 2001 Cancer Research Campaign http://www.bjcancer.com
Keywords: twin, cancer, incidence
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- Akre O., Ekbom A., Hsieh C. C., Trichopoulos D., Adami H. O. Testicular nonseminoma and seminoma in relation to perinatal characteristics. J Natl Cancer Inst. 1996 Jul 3;88(13):883–889. doi: 10.1093/jnci/88.13.883. [DOI] [PubMed] [Google Scholar]
- Cerhan J. R., Kushi L. H., Olson J. E., Rich S. S., Zheng W., Folsom A. R., Sellers T. A. Twinship and risk of postmenopausal breast cancer. J Natl Cancer Inst. 2000 Feb 2;92(3):261–265. doi: 10.1093/jnci/92.3.261. [DOI] [PubMed] [Google Scholar]
- Ekbom A., Erlandsson G., Hsieh C., Trichopoulos D., Adami H. O., Cnattingius S. Risk of breast cancer in prematurely born women. J Natl Cancer Inst. 2000 May 17;92(10):840–841. doi: 10.1093/jnci/92.10.840. [DOI] [PubMed] [Google Scholar]
- Ekbom A. Growing evidence that several human cancers may originate in utero. Semin Cancer Biol. 1998 Aug;8(4):237–244. doi: 10.1006/scbi.1998.0073. [DOI] [PubMed] [Google Scholar]
- Ekbom A., Hsieh C. C., Lipworth L., Adami H. Q., Trichopoulos D. Intrauterine environment and breast cancer risk in women: a population-based study. J Natl Cancer Inst. 1997 Jan 1;89(1):71–76. doi: 10.1093/jnci/89.1.71. [DOI] [PubMed] [Google Scholar]
- Ekbom A., Hsieh C. C., Lipworth L., Wolk A., Pontén J., Adami H. O., Trichopoulos D. Perinatal characteristics in relation to incidence of and mortality from prostate cancer. BMJ. 1996 Aug 10;313(7053):337–341. doi: 10.1136/bmj.313.7053.337. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Harvei S., Tretli S., Langmark F. Quality of prostate cancer data in the cancer registry of Norway. Eur J Cancer. 1996 Jan;32A(1):104–110. doi: 10.1016/0959-8049(95)00501-3. [DOI] [PubMed] [Google Scholar]
- Kringlen E. Norwegian twin registers. Prog Clin Biol Res. 1978;24(Pt B):185–187. [PubMed] [Google Scholar]
- Lichtenstein P., Holm N. V., Verkasalo P. K., Iliadou A., Kaprio J., Koskenvuo M., Pukkala E., Skytthe A., Hemminki K. Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med. 2000 Jul 13;343(2):78–85. doi: 10.1056/NEJM200007133430201. [DOI] [PubMed] [Google Scholar]
- Michels K. B., Trichopoulos D., Robins J. M., Rosner B. A., Manson J. E., Hunter D. J., Colditz G. A., Hankinson S. E., Speizer F. E., Willett W. C. Birthweight as a risk factor for breast cancer. Lancet. 1996 Dec 7;348(9041):1542–1546. doi: 10.1016/S0140-6736(96)03102-9. [DOI] [PubMed] [Google Scholar]
- Platz E. A., Giovannucci E., Rimm E. B., Curhan G. C., Spiegelman D., Colditz G. A., Willett W. C. Retrospective analysis of birth weight and prostate cancer in the Health Professionals Follow-up Study. Am J Epidemiol. 1998 Jun 15;147(12):1140–1144. doi: 10.1093/oxfordjournals.aje.a009412. [DOI] [PubMed] [Google Scholar]
- Stavola B. L., Hardy R., Kuh D., Silva I. S., Wadsworth M., Swerdlow A. J. Birthweight, childhood growth and risk of breast cancer in a British cohort. Br J Cancer. 2000 Oct;83(7):964–968. doi: 10.1054/bjoc.2000.1370. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Swerdlow A. J., De Stavola B. L., Swanwick M. A., Maconochie N. E. Risks of breast and testicular cancers in young adult twins in England and Wales: evidence on prenatal and genetic aetiology. Lancet. 1997 Dec 13;350(9093):1723–1728. doi: 10.1016/s0140-6736(97)05526-8. [DOI] [PubMed] [Google Scholar]
- Swerdlow A. J., De Stavola B. L., Swanwick M. A., Mangtani P., Maconochie N. E. Risk factors for testicular cancer: a case-control study in twins. Br J Cancer. 1999 Jun;80(7):1098–1102. doi: 10.1038/sj.bjc.6690470. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tibblin G., Eriksson M., Cnattingius S., Ekbom A. High birthweight as a predictor of prostate cancer risk. Epidemiology. 1995 Jul;6(4):423–424. doi: 10.1097/00001648-199507000-00017. [DOI] [PubMed] [Google Scholar]
- Verkasalo P. K., Kaprio J., Koskenvuo M., Pukkala E. Genetic predisposition, environment and cancer incidence: a nationwide twin study in Finland, 1976-1995. Int J Cancer. 1999 Dec 10;83(6):743–749. doi: 10.1002/(sici)1097-0215(19991210)83:6<743::aid-ijc8>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
- Windham G. C., Bjerkedal T., Langmark F. A population-based study of cancer incidence in twins and in children with congenital malformations or low birth weight, Norway, 1967-1980. Am J Epidemiol. 1985 Jan;121(1):49–56. doi: 10.1093/oxfordjournals.aje.a113982. [DOI] [PubMed] [Google Scholar]
