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. 2001 Aug;85(4):518–522. doi: 10.1054/bjoc.2001.1942

IL-6 gene amplification and expression in human glioblastomas

A Tchirkov 1,2, C Rolhion 1,3, S Bertrand 4, J-F Doré 4, J-J Dubost 5, P Verrelle 1,3
PMCID: PMC2364101  PMID: 11506489

Abstract

The aggressiveness of human gliomas appears to be correlated with the upregulation of interleukin 6 (IL-6) gene. Using quantitative PCR methods, we detected amplification and expression of the IL-6 gene in 5 of 5 primary glioblastoma samples and in 4 of 5 glioblastoma cell lines. This finding suggests that the amplification of IL-6 gene may be a common feature in glioblastomas and may contribute to the IL-6 over-expression. © 2001 Cancer Research Campaign http://www.bjcancer.com

Keywords: IL-6, gene amplification and expression, glioblastoma

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Selected References

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