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. 2002 Apr 8;86(7):1197–1203. doi: 10.1038/sj.bjc.6600179

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Copyright © 2002 Cancer Research UK

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The effect of a single dose of ²¹³Bi-PAI2 on the growth of s.c. xenografts of PC3 human hormone-independent prostate cancer in nude mice with local and systemic injections. The arrows indicate the start of each treatment. (A) Single intra-lesional injections of 50 and 25 μCi of ²¹³Bi-PAI2 or 50 μCi of ²¹³Bi-BSA non specific control and PBS buffer were given 2-days post inoculation. (B) Single i.p. injections of a series 1.5, 3.0, 6.0 mCi kg⁻¹ of ²¹³Bi-PAI2 or 6.0 mCi kg⁻¹ of ²¹³Bi-BSA were given 2-days post inoculation. (C) Single i.p. injections of 3 and 6 mCi kg⁻¹ of ²¹³Bi-PAI-2 or single equal amount of PAI2 (0.4 mg kg⁻¹) were given when tumour volume was 30–40 mm³. (D) Single i.p. injections of 3 and 6 mCi kg⁻¹ ²¹³Bi-PAI2 or single equal amount of cDTPA-PAI2 were given when tumour volume was 85–100 mm³. No death related to toxicity occurred. Data are expressed as the mean±s.d. for five tumours.