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. 2002 Sep 9;87(6):630–634. doi: 10.1038/sj.bjc.6600511

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Copyright © 2002 Cancer Research UK

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Kaplan–Meier plotting of survival in response to 5FU therapy in patients (n=202) with SMAD4 deletion (top) and with no loss of SMAD4 (bottom). Overall survival (left): HR=3.23, 95% CI=0.97–10.8, P=0.056. Disease-free survival (right): HR=2.89, 95% CI=1.02–8.12, P=0.045.