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. 2002 Jul 15;87(1):113–118. doi: 10.1038/sj.bjc.6600342

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Copyright © 2002 Cancer Research UK

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(A,B) TGF-β2 enriched fraction and recombinant TGF-β3 comparably inhibit proliferation and protect cells against Ara-C induced toxicity by induction of G1-phase arrest. In Figure 1A, BrdU incorporation into IEC-6 cells incubated for 48 h with a concentration range of recombinant TGF-β3 (closed triangles) or the TGF-β2 enriched fraction (open triangles) is shown. The data represent mean±s.d. of three independent experiments. In Figure 1B, G1-phase arrest is detected by flowcytometry-analysis of propidium iodide labelled IEC-6 cells incubated with recombinant TGF-β3 or the TGF-β2 enriched fraction in the presence or absence of Ara-C. A total of 10 000 cells were counted and divided into three sections, of which G1-phase represents cells with N amount of DNA, G2-phase represents the cells in proliferating phase i.e. containing N2 amount of DNA and the remaining dying cells (amount <N).