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. 2002 Jul 15;87(1):113–118. doi: 10.1038/sj.bjc.6600342

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Copyright © 2002 Cancer Research UK

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(A,B) Epithelial cells are protected against cell cycle specific drug, due to TGF-β2 present in TGF-β2 enriched fraction. Cell viability of IEC-6 cells after treatment with a concentration range of Ara-C (A) or MTX (B), incubated with (closed triangle) or without (closed square) TGF-β2 enriched fraction is shown. The open triangles (A) show cells, which were incubated with TGF-β2 enriched fraction after blocking of TGF-β2 activity by pre-incubation with anti-TGF-β2 antibodies. Mean±s.d. of three individual experiments is shown. Statistical differences between viability of cells incubated with TGF-β2 enriched fraction after depletion for TGF-β2 and control or TGF-β2 alone are indicated with #(P<0.05) or *(P<0.01).