Figure 6.
Investigation of the effect on Panc-1 cytolysis of antibody blockade of ICAM-1 or CD103. The effector T cells were harvested from an MLR performed in the presence of TGFβ1 and were additionally stimulated with anti-CD3 antibody prior to addition to the target cells. The hatched bar shows control cytolysis of the antigen-presenting cells used for T cell activation, the open bar shows the lysis of E-cadherin transfected Panc-1 in the presence of a control antibody, the shaded bar shows the effect of ICAM-1 blockade, the solid bar shown the effect of CD103 blockade and the horizontally filled bar shows lysis of wild-type Panc-1 cells. The bars show the mean of 10-fold determinations; the error bars show the s.e.m.