Figure 3.

Slices from R(AB) mice exhibit intact β-adrenergic receptor-dependent enhancement of LTP maintenance. (A) In slices from wild-type mice, application of ISO during one train of HFS induces long-lasting LTP, whereas one train of HFS alone induces decremental LTP. (B) Application of ISO during one train of HFS in mutant slices similarly induces long-lasting LTP. (C) Summary histogram for these experiments comparing levels of potentiation 5 min after HFS. (D) Summary histogram for these experiments comparing levels of potentiation 120 min after HFS (*P < 0.05). All sample traces were taken 10 min after commencement of baseline recording and 120 min after HFS. Calibration: 5 mV, 2 msec.