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. 2008 May;15(5):357–367. doi: 10.1101/lm.902708

Figure 2.

Figure 2.

Cannula positions and the extent of hippocampal lesions. (A) Histological verifications of the cannula positions in mPFC in the HP-LES and HP-CTRL groups. (B) Illustration of the positions of the injection cannula tips in mPFC (◦, HP-CTRL group; ●, HP-LES group). The anterior-posterior stereotaxic coordinates of sections are given by the numbers above the sections. Illustrations are modified from Paxinos and Watson (1986). (C) Histological verifications of the hippocampal and control lesions. Three different sections along the anterior-posterior axis are shown to demonstrate the full extent of lesions in both dorsal and ventral hippocampal regions in the HP-LES group. The HP-CTRL group showed intact hippocampi. (D) Examples of three-dimensionally reconstructed cell layers in the intact hippocampus (HP-CTRL group) and lesioned hippocampus (HP-LES group), providing a dorsolateral view of the reconstructed image (see orientation arrows). Remaining cell layers from the HP-LES group were superimposed on the control group’s image (light gray) for illustrative purposes. Compared to the control-lesioned hippocampus, the neurotoxic lesions of the hippocampus only left minor cell layers at the dorsal and ventral tips in the whole hippocampus.