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. 2008 May;15(5):378–386. doi: 10.1101/lm.886208

Figure 5.

Figure 5.

Inhibition of fear memory extinction is not centrally mediated. (A) Experimental design. (B,C) Percentage of freezing during contextual fear acquisition and extinction sessions. WT mice were injected i.c.v. 10 min before the extinction session with vehicle (n = 7) or 50 μg/kg of nifedipine (n = 7). (D,E) Percentage of freezing during contextual fear acquisition and extinction sessions. WT mice were injected i.c.v. 10 min before the extinction session with vehicle (n = 10) or 200 μg/kg of nifedipine (n = 9). (F,G) % of freezing during contextual fear acquisition and extinction sessions. WT mice were injected i.c.v. 10 min before the extinction session with vehicle (n = 10) or 1 mg/kg of nifedipine (n = 8). (H) Percent of freezing during a long-term extinction session. Vehicle- and nifedipine- (1 mg/kg) treated groups when tested 24 h later in drug-free conditions. Data are presented as mean ± SEM. Statistical analysis was performed using a 2-way ANOVA. *P < 0.05, WT nifedipine vs. vehicle.