Table 1.
Region | Country | Study Identification* [Ref] | Treatment Group | Number of Patients Studied | Total Number of Patients | ||
Moderately Severe | Severe | Uncomplicated | |||||
Africa | Ghana | Krishna 1996 [10] | Artesunate ir, single dose | 23 | 23 | ||
Artemisinins** parenteral | 11 | 11 | |||||
Kenya | Bhatt 1994–5 [36] | Artesunate ir, multiple dose | 23 | 23 | |||
Malawi | Molyneux 1997–8 [30] | Artesunate ir, single dose | 86 | 86 | |||
Quinine parenteral | 22 | 22 | |||||
South Africa | Barnes 1998 [30] | Artesunate ir, single dose | 27 | 27 | |||
Quinine parenteral | 8 | 6 | 14 | ||||
Quinine parenteral+ Artesunate ir | 5 | 5 | |||||
Uganda | Aceng 2002–3 [32] | Artemether ir, single dose | 51 | 51 | |||
Quinine parenteral | 52 | 52 | |||||
Total Number of Patients – Africa | 177 | 137 | 314 | ||||
Asia- Oceania | Myanmar | Than 1998 | Artesunate ir, multiple dose | 100 | 100 | ||
Papua New Guinea | Karunajeewa 2001 [37] | Artesunate ir, multiple dose | 48 | 48 | |||
Papua New Guinea | Karunajeewa 2003–4 [34] | Artesunate ir, multiple dose | 41 | 41 | |||
Artemisinins parenteral | 38 | 38 | |||||
Thailand | Looareesuwan 1996 | Artesunate ir, single dose | 26 | 26 | |||
Artemisinins parenteral | 24 | 24 | |||||
Thailand | Van Vugt 1997–9 | Artesunate ir, single dose | 44 | 44 | |||
Artesunate po | 17 | 17 | |||||
Thailand | Looareesuwan 1995 [35] | Artesunate ir, multiple dose | 60 | 60 | |||
Thailand | Looareesuwan 2000 | Artesunate ir, single dose | 69 | 69 | |||
Vietnam | Phuong 1992–5 [31] | Artemisinin, multiple dose | 46 | 46 | |||
Artemisinins parenteral | 40 | 40 | |||||
Quinine parenteral | 35 | 35 | |||||
Vietnam | Vinh 1992–4 [33] | Artemisinin ir, multiple dose | 52 | 52 | |||
Artemisinins parenteral | 123 | 123 | |||||
Vietnam | Hien 1998 | Artemisinin ir, single dose | 46 | 46 | |||
Artesunate ir, single dose | 44 | 44 | |||||
Total Number of Patients – Asia | 240 | 565 | 48 | 853 | |||
Grand Total | 417 | 702 | 48 | 1167 |
* Study Identification: Investigator name and year of patient enrolment [References are included where available].
** Artemisinins parenteral: this consisted of Artemether or Artesunate administered via intra-muscular or intravenous route