Table 4.
Parasite reduction ratio at 12 and 24 hours: Mixed model results
| 12 hr final model | 24 hour descriptive model** | 24 hr final model | |||||||
| % | p-value | N | % | p-value | N | Odds Ratio | p-value | N | |
| Single Rectal Artemisinin or Artesunate vs Parenteral Artemisinins | |||||||||
| Parenteral | 45.7 | 225 | 83.8 | 49 | 179 | ||||
| Rectal | 59.1 | 0.018 | 339 | 90.0 | 0.069 | 331 | 1.75* | 0.072 | 201 |
| Severe malaria | 16.6 | 0.008 | |||||||
| Multiple Artesunate vs Single Artesunate | |||||||||
| Single artesunate | 57.7 | 169 | 93.7 | 80 | 155 | ||||
| Multiple artesunate | 32.7 | 0.001 | 249 | 87.5 | 0.279 | 307 | 0.19 | 0.004 | 232 |
| Total dose at 24 hours | 19.5 | 0.011 | 1.14 | 0.008 | |||||
| Single Artemisinin vs Single Artesunate | |||||||||
| Single artesunate | 64.2* | 169 | 93.9 | 46 | 46 | ||||
| Single artemisinin | 72.3 | 0.262 | 46 | 95.5 | 0.792 | 155 | 1.13* | 0.813 | 155 |
| Multiple Artemisinin vs Single Artemisinin | |||||||||
| Single artemisinin | 72.3 | 46 | 95.5 | 80 | 80 | ||||
| Multiple artemisinin | 63.2 | 0.545 | 98 | 89.1 | 0.348 | 46 | 0.60* | 0.403 | 46 |
| Single Artemether vs Single Artesunate | |||||||||
| Single artesunate | 73.5 | 51 | 96.7 | 109 | 109 | ||||
| Single artemether | 53.5 | 0.000 | 124 | 83.1 | 0.000 | 41 | 0.22* | 0.002 | 41 |
* No solution was found for the mixed model. Corresponding non-hierarchical regression used instead.
** Descriptive estimates of parasite reductions at 24 hours are provided only for comparisons with 12 hour estimates, see section 'Statistical analysis'