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. 2008 May 16;4(5):e1000068. doi: 10.1371/journal.ppat.1000068

Figure 4. Gene network analysis identifies putative mediators of PbA-induced ALI.

Figure 4

A gene-gene interaction network of differentially expressed lung homogenate cytokines and defense/immune response genes in the PbA infection model was created from known gene product interaction databases (Ingenuity, Adriadne and Human Protein Reference Database). Red circles denote upregulated genes and green downregulated genes. Nodes with high interconnectivity, including IFN-γ, TNF and IL-6, may be important mediators of PbA-induced ALI.