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. 2008 May 16;4(5):e1000068. doi: 10.1371/journal.ppat.1000068

Figure 7. Cd36−/− mice develop significantly less ALI than wild-type mice.

Figure 7

Previous studies have demonstrated that P. berghei binds in a CD36-dependent manner and sequesters preferentially in the lungs of infected mice. Hypothetically, mice with reduced lung parasite burden would be protected from the development of ALI. A. Infected Cd36−/− mice showed decreased BALF IgM concentration at Day 7 post infection compared to wildtype controls (2-tailed t-test, ***p<0.0001); however, B. Cd36+/+ and Cd36−/−mice developed equivalent peripheral parasitemias and died from CM during the same time frame (data not shown). Nine CD36−/− mice and 10 Cd36+/+ mice were used per group, and the data are representative of two independent experiments. Therefore, ALI in this model is CD36-dependent.