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. 2008 May 5;181(3):421–429. doi: 10.1083/jcb.200711053

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© 2008 Goshima et al.

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Figure 5. — Model for augmin-dependent MT amplification in the spindle. (A) MTs are initially nucleated from centrosomes (brown) and near chromosomes/kinetochores (blue) in early prometaphase. γ-TuRC (red) is the major nucleator of these MTs. (B) The augmin/γ-TuRC machinery (yellow/red) then binds to those MTs, preferably to stable ones such as kMTs, and nucleates new MTs. The new MTs, which are oriented parallel or slightly angled to the template MTs, contribute to K-fiber generation and net kinetochore capture by the search-and-capture mechanism.