Table 1. Study population.
|
Examined or known cardiac failure (n=229) |
|||||
|---|---|---|---|---|---|
| Whole population (n=447) | Not examined and not known cardiac failure (n=218) | Cardiac failure (n=24) | Asymptomatic patients examined (n=205) | P-valuea | |
| Date of first adriamycin dose | 1978 (1968–1982) | 1978 (1972–1983) | 1978 (1973–1985) | 1978 (1968–1984) | NS |
| Sex (M/F) | 278/169 | 145/73 | 14/10 | 119/86 | 0.1 |
| First cancer type | |||||
| Unknown | 3 | 1 | 0 | 2 | |
| Lymphoma | 138 | 67 | 3 | 68 | |
| Neuroblastoma | 64 | 25 | 6 | 33 | |
| Nephroblastoma | 56 | 21 | 8 | 27 | NS |
| Soft-tissue sarcoma | 91 | 54 | 1 | 36 | |
| Osteosarcoma | 15 | 5 | 1 | 9 | |
| Ewing sarcoma and PNET | 33 | 19 | 2 | 12 | |
| Hepatoblastoma | 8 | 4 | 0 | 4 | |
| UCNT and other carcinoma | 7 | 2 | 1 | 4 | |
| Others | 32 | 20 | 2 | 10 | |
| First cancer site | |||||
| Unknown | 2 | 1 | 0 | 1 | |
| Brain and spinal axis | 5 | 2 | 1 | 2 | |
| Skull, face and orbit | 51 | 28 | 0 | 23 | |
| Cervical | 51 | 20 | 1 | 30 | |
| Thorax and mediastinum | 49 | 20 | 5 | 24 | |
| Retroperitoneum | 126 | 56 | 11 | 59 | |
| Abdominal cavity | 45 | 22 | 0 | 23 | |
| Pelvis | 52 | 32 | 3 | 17 | |
| Rachis | 17 | 12 | 1 | 4 | |
| Limbs | 49 | 25 | 2 | 22 | |
| Age at first anthracycline dose (min–max) | 6.2 (0–21) | 6.9 (0–16) | 4.8 (1–13) | 5.7 (0–21) | 0.005 |
| Total anthracycline dose: mean (min–max) (mg m−2) | 344 (40–600) | 347 (60–600) | 412 (180–600) | 333 (40–600) | 0.05 |
| Radiotherapy: n (%) | 245 (55%) | 125 (57%) | 14 (58%) | 106 (52%) | 0.3 |
| Radiation dose to the heart: mean (min–max) (Gy) | 6.7 (0–91) | 5.2 (0–35) | 13.4 (0–46) | 7.7 (0–91) | 0.3 |
| Maximal radiation dose at a point in the heart: mean (min–max) (Gy) | 31.3 (0–125) | 32.5 (0–102) | 37.3 (0–745) | 31.5 (0–125) | 0.5 |
a
Comparison between the 205 pts not examined and the others.