Table 6. Dose–response relationship between the average radiation dose to the heart and the occurrence of a cardiac abnormality in 229 patients with known cardiac status.
|
Cardiac abnormalitya |
|||
|---|---|---|---|
| Parameters | % (nb/N) | Relative riskb and 95% CI | P-value |
| Average radiation dose | |||
| 0 (no radiotherapy) | 29% (32/109) | 1c | |
| >0–5 Gy | 37% (25/68) | 1.63 (0.82–3.26) | |
| >5–20 Gy | 63% (26/41) | 6.48 (2.76–15.20) | <0.001 |
| >20 Gy | 55% (6/11) | 4.40 (1.11–17.48) | |
a
At least one of the following criteria: cardiac failure, FS<25, ES<50, or ESWS>100.
b
Adjusted for age at treatment of 1st cancer, sex, and cumulative anthracyline dose, and stratified on the site of the cancer.
c
Reference category.