Table 7. Frequency of cardiac abnormality in 229 pts according to the cumulative dose of adriamycin and to the average radiation dose received to the heart.
| Parameters |
Cardiac abnormalitya |
||
|---|---|---|---|
| Cumulative dose of adriamycin and average radiation dose to the heart | % (nb/N) | Relative riskb and 95% CI | P-value |
| <250 mg of adriamycin | |||
| <5 Gy to the heart | 11% (4/32) | 1c | |
| ⩾5 Gy to the heart | 44% (8/18) | 4.9 (1.3–18.0) | 0.02 |
| ⩾250 mg of adriamycin | |||
| <5 Gy to the heart | 38% (53/141) | 5.1 (1.8–14.5) | 0.003 |
| ⩾5 Gy to the heart | 71% (24/34) | 6.6 (2.1–20.6) | 0.001 |
a
At least one of the following criteria: cardiac failure, FS<25, ES<50, or ESWS>100.
b
Adjusted for age at treatment of first cancer, and sex, and stratified on the site of the cancer.
c
Reference category.