Table 3. Associations between UGT1A1*28 genotypes and grade III–IV toxicities.
| Genotypea | N | Asthenia | Diarrhoea | Haematological | Nausea | Mucositis | Infection |
|---|---|---|---|---|---|---|---|
| 6/6 | 40 | 10 (25%) | 7 (17%) | 6 (15%) | 5(12%) | 1 (3%) | 6 (15%) |
| 6/7 | 45 | 17 (38%) | 15 (33%) | 12 (27%) | 10 (22%) | 2 (4%) | 2 (4%) |
| 7/7 | 10 | 7 (70%) | 7 (70%) | 4 (40%) | 2 (20%) | 0 (0%) | 0 (0%) |
| P | — | 0.03 | 0.005 | 0.2 | 0.4 | 0.4 | 0.13 |
a
Symbols of (6/6), (6/7), and (7/7) denote homozygous absence of the variant allele, heterozygous and homozygous for the variant allele, respectively. Bold values refer to statistically significant values.