Table 5. Clinical and pathological features and PPARγ expression in papillary carcinomas.
|
PPARγ immunohistochemistry |
||||
|---|---|---|---|---|
| PTC | All (n=39) | Negative (n=20) | Positive (n=19) | P-value |
| Age at diagnosis (years±s.d.) | 41.0±19.9 | 38.7±18.7 | 43.5±21.3 | NS |
| F/M ratio | 2.5/1 | 1.9/1 | 3.4/1 | NS |
| Tumour size (cm±s.d.) | 3.7±2.4 | 3.9±2.1 | 3.5±2.3 | NS |
| MACIS (mean±s.d.) | 5.5±1.8 | 5.6±2.0 | 5.5±1.7 | NS |
| Classa | NS | |||
| I | 20 | 11 (55%) | 9 (45%) | |
| II | 6 | 3 (50%) | 3 (50%) | |
| III | 9 | 2 (22%) | 7 (78%) | |
| IV | 3 | 3 (100%) | 0 | |
| Predominant pattern | 0.01 | |||
| Classic | 18 | 5 (28%) | 13 (72%) | |
| Follicular | 15 | 12 (80%) | 3 (20%) | |
| Others | 6 | 3 (50%) | 3(50%) | |
| Poorly differentiated areas | 6 | 4 (67%) | 2 (33%) | NS |
| Local invasion | 13 | 6 (46%) | 7 (54%) | NS |
| Vascular invasion | 9 | 4 (44%) | 5 (56%) | NS |
| Clinical statusa | NS | |||
| Persistent | 9 | 3 (33%) | 6 (67%) | |
| Remission | 29 | 16 (55%) | 13 (45%) | |
PPAR=peroxisome proliferator-activated receptor; PTC=papillary thyroid carcinoma; s.d.=standard deviation; NS=not significant.
a
Loss of follow-up of one patient.