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. 2004 Jul 13;91(4):775–782. doi: 10.1038/sj.bjc.6602021

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Copyright © 2004 Cancer Research UK

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Comparative genomic hybridisation (A, B) and hierarchical clustering (C) of two bilateral breast carcinomas (case 7) together with other 35 breast carcinomas with copy number changes (coded by chromosome arm). Green bars to the right and red bars to the left of the chromosome ideograms indicate copy number gains and losses, respectively. See Table 1 for case numbers and a detailed description of the genomic imbalances. The two carcinomas segregate apart (asterisks), showing that they are pathogenetically more similar to tumours in other women than to one another. This is taken as indication that these bilateral carcinomas are clonally independent.