Table 4. c-erbB-2 mRNA expression and regression (sensitivity and specificity of response prediction).
|
Regression grading |
|||
|---|---|---|---|
| c-erbB-2a | Grades I/II (MiHRb) | Grades III/IV (MaHRc) | Total: n (%) |
| ⩽1 or ⩽1.06: n (%)d | 14 (38.9%) | 12 (33.3%) | 26 (72.2%) |
| >1 or >1.06: n (%)d | 10 (27.8%) | ∅ | 10 (27.8%) |
| Total: n (%) | 24 (66.7%%) | 12 (33.3%) | 36 (100%) |
a
Dichotomised c-erbB-2 mRNA levels.
b
Minor histopathologic response.
c
Major histopathologic response.
d
All values remain identical if maximum cutoff at 1.06 was chosen from ROC curves. χ2-analysis (Fisher's exact test): P=0.015.
Prediction of MiHR (c-erbB2 >1): sensitivity 41.6%, specificity: 100%.