Table 5. c-erbB-2 mRNA expression and regression in SCCa (sensitivity and specificity of response prediction).
|
Regression grading |
|||
|---|---|---|---|
| c-erbB-2b | Grades I/II (MiHRc) | Grades III/IV (MaHRd) | Total: n (%) |
| ⩽1 or ⩽1.06e: n (%) | 8 (34.8%) | 9 (39.1%) | 17 (73.9%) |
| >1 or >1.06e: n (%) | 6 (26.1%) | ∅ | 6 (26.1%) |
| Total: n (%) | 14 (60.9%) | 9 (39.1%) | 23 (100%) |
a
Squamous cell cancer.
b
Dichotomised c-erbB-2 mRNA levels.
c
Minor histopathologic response.
d
Major histopathologic response.
e
All values remain identical if maximum cutoff at 1.06 was chosen from ROC curves. χ2-analysis (Fisher's exact test): P=0.048.
Prediction of MiHR (c-erbB-2 >1): sensitivity 42.8%, specificity: 100%.