Table 6. c-erbB-2 mRNA expression and regression in ACa (sensitivity and specificity of response prediction).
|
Regression grading |
|||
|---|---|---|---|
| c-erbB-2b | Grades I/II (MiHRc) | Grades III/IV (MaHRd) | Total: n (%) |
| ⩽1 or ⩽1.06e: n (%) | 6 (46.2%) | 3 (23.1%) | 9 (69.2%) |
| >1 or >1.06e: n (%) | 4 (30.8%) | ∅ | 4 (30.8%) |
| Total: n (%) | 10 (76.9%) | 3 (23.1%) | 13 (100%) |
a
Adenocarcinoma.
b
Dichotomised c-erbB-2 mRNA levels.
c
Minor histopathologic response.
d
Major histopathologic response.
e
All values remain identical if maximum cutoff at 1.06 was chosen from ROC curves. χ2-analysis (Fisher's exact test): not possible (three cells with expected frequencies <5).
Prediction of MiHR (c-erbB-2 >1): sensitivity 40%, specificity: 100%.