Table 3. Results of Cox's proportional-hazard regression analysis (univariate) of metastatic rate on A-1012G, Fok 1 and Taq 1 genotypes, and on A-1012G genotype combinations with Fok 1 and Taq 1.
| Polymorphisms | Genotype | Number | HR | 95% CI | Significance |
|---|---|---|---|---|---|
| A-1012G | GG/AG | 110 | 1 | ||
| AA | 59 | 2.9 | 1.1–7.5 | P=0.03 | |
| Fok | FF/Ff | 140 | 1 | ||
| Ff | 30 | 1.3 | 0.4–4.1 | P=0.6 | |
| Taq | TT/Tt | 143 | 1 | ||
| Tt | 26 | 1.5 | 0.5–4.6 | P=0.5 | |
| Fok/Taq | Other genotypes | 165 | 1 | ||
| ff/tt | 4 | 2.2 | 0.3–16.3 | P=0.5 | |
| A-1012G/Taq | Other genotypes | 130 | 1 | ||
| AATT | 27 | 2.5 | 0.9–7.4 | P=0.1 | |
| Aatt | 11 | 3.1 | 0.8–11.2 | P=0.1 | |
| A-1012G/Fok | Other genotypes | 130 | 1 | ||
| AAFF | 30 | 4.3 | 1.5–12.4 | P=0.006 | |
| AAff | 9 | 8.6 | 2.5–29.6 | P=0.001 | |
| AAFF/Ff | 50 | 1 | |||
| AAff | 9 | 4.7 | 1.2–18.6 | P=0.03 |
HR=hazard ratio; CI=95% confidence interval for hazard ratio estimate. Bold numerals represent statistically significant results.