In Vitro Antitumour Activity of Some Triorganophosphinegold(I) Thionucleobases

Abstract

A series of phosphinegold(I) thionucleobase analogues, [R₃PAu(SR^x)] (R = Et, Ph or chexyl; HSR¹ = 2-mercaptobenzoic acid, HSR² = 2-thiouracil, HSR³ = 6-mercaptopurine and HSR⁴ = 6-thioguanine) have been examined for their in vitro cytotoxicity in L1210 murine leukemia cells in culture. The range of ID₅₀ values (continuous 48 h exposure) for the complexes is 0.041 - 0.131 μM. The complexes with SR³ and SR³ are generally the most active; however, there is no clear trend associated with the phosphine ligands.

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