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. Author manuscript; available in PMC: 2008 May 2.
Published in final edited form as: Cell Calcium. 2006 Mar 7;39(5):445–454. doi: 10.1016/j.ceca.2006.01.005

Fig. 8.

Fig. 8

Activation of CaMKII is independent of VGCC-mediated Ca2+ influx. Pre-incubation with either the L-type channel blockers isradipine or SR 33805 (n = 6) at 10 μM failed to block CaMKII activation. Additionally, the Na+/Ca2+-exchanger inhibitor KB-R7943 at 10 μM (n = 6) also did not affect activation of CaMKII by Ca2+O-stimulation. Basal phosphorylation at 286/287Thr in 0 Ca2+ was 12 ± 1% of stimulation by 1.8 Ca2+O. Neither compound significantly affected Ca2+-stimulation (n = 6) suggesting that changes in [Ca2+]O act at a site independent of VGCC.