Table 2.
Treatment | No. of ganglion pairs analyzed | Mean (± SD) gene copy Numberb |
---|---|---|
Untreated | 20 | 1.4 × 106 ± 0.9 × 101 |
Oral vehicle | 10 | 1.4 × 106 ± 0.8 × 101 |
Oral BAY 57-1293 | 20 | 2.4 × 102 ± 0.5 × 101 |
Latent mice were heat-stressed and not treated, vehicle-treated, or drug-treated by oral administration. Twenty-four (24) h later, the mice were euthanized and their ganglia analyzed for viral DNA.
The mean number of viral polymerase gene copies in the ganglia of the mice treated orally with BAY 57-1293 was significantly smaller than the numbers of copies in the ganglia from the other groups of mice (P < 0.0001).