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Joint effects of polymorphisms of Aurora-A and p16 on risk for diagnosis of pancreatic cancer at an early age
| Genotypes Aurora-A | p16 C580T | n (%), N = 148 | Median age at diagnosis (y) | HR (95% CI) |
|---|---|---|---|---|
| (T→A) | (C→T) | |||
| TT | CC | 83 (56.1) | 63.4 | 1.00 (reference) |
| TT | CT/TT | 18 (12.2) | 59.1 | 1.29 (0.77–2.15) |
| TA/AA | CC | 37 (25.0) | 60.5 | 1.41 (0.95–2.10) |
| TA/AA | CT/TT | 10 (6.7) | 50.8 | 3.88 (1.94–7.76)* |
P < 0.05, departure from additive model.
