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. 2008 Apr 28;105(18):6782–6786. doi: 10.1073/pnas.0801038105

Fig. 2.

Fig. 2.

Amino acid polymorphism in Top1s of CPT-producing plants and nonproducing organisms. Shown are proposed amino acids that are involved in catalytic function or affect CPT binding. Asp-533 and Ser-722 directly bind to CPT. Other residues that indirectly bind to CPT are important for the proper positioning of Asp-533 and Ser-722. The numbering is based on HsTop1. The red characters indicate the amino acid substitutions in Top1s of CPT-producing plants. Hs, Homo sapiens; At, Arabidopsis thaliana; Cr, Catharanthus roseus; Oj, Ophiorrhiza japonica; Op, Ophiorrhiza pumila; Ol, Ophiorrhiza liukiuensis; Ca, Camptotheca acuminata.