Table 2.

Voxel-based morphometry results for AS’s scan for each year compared to 15 age-matched controls.

Brain area (BA)	YEAR 1		YEAR 2		YEAR 3		YEAR 4
	coordinates	Z score	coordinates	Z score	coordinates	Z score	coordinates	Z score
Left inf frontal gyrus	−53, 12, 18	4.4	−53, 12, 18	4.9*	−54, 12, 16	5.2*	−54, 12, 14	5.7*
pars opercularis (44)	−57, 6, 9	3.7	−57, 6, 9	4.2	−57, 6, 9	4.5	−44, 7, 4	5.5*
	—		—		—		−47, 16, 5	5.5*
pars triangularis (45)	—		—		—		−49, 27, 6	5.0*
pars orbitalis (47)	—		−47, 38, 3	3.1	−47, 41, 4	3.4	−45, 38, 3	4.5
Left insula	−44, 7, 4	3.3	−44, 7, 4	4.0	−44, 7, 4	4.9*	−44, 7, 4	5.5*
	−34, 22, −7	2.7	−34, 22, −7	3.1	−34, 22, −7	3.8	−35, 21, −8	5.0*
Left inf central sulcus/subcentral gyrus (43)	—		−61, −19, 17	4.1	−61, −19, −17	4.6	−61, −19, 18	4.7
Left frontal pole (10)	−40, 56, −1	3.5	−39, 56, 0	3.9	−39, 56, 0	4.4	−39, 56, 0	4.3
	—		—		—		−48, 38, 3	4.6
Medial frontal (6/8/9/10)	−6, 40, 20	3.5	−6, 40, 20	3.7	−6, 42, 20	3.7	−6, 45, 24	3.6
							−5, −2, 60	3.2
	−6, 15, 48	3.7	−6, 14, 49	3.4	−5, 15, 51	3.7	6, 20, 55	5.1*
							7, −2, 62	4.6
	—	—	7, 65, −7	3.2	7, 65, −7	3.2	7, 63, −8	4.6
Left caudate	—		—		—		−14, 15, 5	3.7
Right caudate	—		—		—		15, 18, 2	3.1
Left anterior temporal (38/21)	−39, 20, −36	4.1	−38, 20, −36	4.3	−39, 20, −36	4.5	−38, 20, −37	4.8
	−53, 12, −28	4.0	−53, 12, −28	4.0	−53, 12, −28	4.1	−53, 12, −27	4.6
	—		−57, 7, 13	3.8	−58, 6, −14	4.3	−57, 7, −13	4.6
Left thalamus	—		−6, −14, −2	3.7	−5, −19, 5	3.9	−5, −20, 7	4.1
			−5, −20, 6	3.5	−4, −22, 2	3.8	−4, −24, 1	4.0
Left angular gyrus (39)	—		—		−53, −68, 26	3.7	−53, −68, 30	4.0
Left inf temporal gyrus (37)	—		−65, −45, −13	3.7	−65, −45, −11	3.9	−66, −39,−16	4.6
Left sup parietal lobule (7)	—		−21, −55, 67	4.4	−21, −55, 67	4.7	−19, −51,69	4.3

^*p < 0.05 corrected for multiple comparisons.