Table 2.

Metabolite Concentrations (Arbitrary Units) in LD and HD and in Alcohol-Dependent HD: Men and Women Combined (mean ± SD)

Metabolite	Region of interest	All LD (n = 52)	All HD (n = 46)	LD vs. HD	Dependent HD (n = 41)	LD vs. dependent HD
NAA	Fro WMa	32.91 ± 4.38	31.11 ± 4.21	F(2,89) = 4.30; p = 0.04	30.96 ± 4.32	F(2,84) = 3.59; p = 0.06
	Fro GM	34.73 ± 3.43	34.70 ± 4.61	NS	34.70 ± 4.71	NS
	Par WM	30.86 ± 4.23	30.22 ± 4.49	NS	30.22 ± 4.64	NS
	Par GM	32.93 ± 3.43	33.57 ± 4.07	NS	33.66 ± 3.92	NS
Cr	Fro WM	18.98 ± 2.21	19.75 ± 2.94	F(2,91) = 2.07; p = 0.15	19.92 ± 2.95	F(2,86) = 2.97; p = 0.09
	Fro GM	22.95 ± 3.22	23.33 ± 3.23	NS	23.72 ± 3.28	NS
	Par WM	17.53 ± 2.49	18.37 ± 2.55	F(2,78) = 2.36; p = 0.13	18.72 ± 2.40	F(2,73) = 3.97; p = 0.05
	Par GM	19.99 ± 2.17	21.50 ± 2.88	F(2,93) = 8.44; p = 0.005	21.79 ± 2.75	F(2,88) = 11.95; p = 0.0008
Cho	Fro WM	6.45 ± 1.08	6.17 ± 1.13	NS	6.27 ± 1.14	NS
	Fro GM	6.47 ± 1.25	6.59 ± 1.29	NS	6.79 ± 1.27	NS
	Par WM	5.38 ± 0.94	5.38 ± 1.00	NS	5.54 ± 0.99	NS
	Par GM	5.06 ± 0.63	5.31 ± 0.73	F(2,92) = 3.30; p = 0.07	5.41 ± 0.71	F(2,87) = 5.75; p = 0.02
mI	Fro WM	17.74 ± 3.51	17.77 ± 3.03	NS	18.06 ± 2.93	NS
	Fro GM	21.02 ± 4.19	20.37 ± 3.00	NS	20.69 ± 2.98	NS
	Par WM	17.57 ± 2.73	18.15 ± 2.85	NS	18.53 ± 2.52	NS
	Par GM	17.74 ± 2.54	18.94 ± 3.29	F(2,92) = 3.84; p = 0.05	19.16 ± 3.23	F(2,87) = 4.74; p = 0.03
NAA	Brainstem	33.14 ± 5.08	32.48 ± 5.16	NS	31.82 ± 4.69	NS
	Thalamus	36.97 ± 4.54	37.21 ± 4.77	NS	37.12 ± 4.82	NS
Cr	Brainstem	27.58 ± 3.25	29.04 ± 5.10	NS	28.46 ± 4.57	NS
	Thalamus	24.66 ± 2.67	25.00 ± 3.43	NS	25.22 ± 3.43	NS
Cho	Brainstem	8.03 ± 1.41	8.21 ± 1.42	NS	8.04 ± 1.35	NS
	Thalamus	7.10 ± 1.00	6.99 ± 1.06	NS	7.05 ± 1.07	NS
mI	Brainstem	22.86 ± 4.68	23.28 ± 5.78	NS	22.64 ± 5.48	NS
	Thalamus	20.22 ± 3.37	20.75 ± 3.85	NS	21.07 ± 3.90	NS

Fro, frontal; Par, parietal; NS, not significant.

^aFemale HD versus female LD: − 13%; F(2,24) = 3.77; p = 0.06.