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. Author manuscript; available in PMC: 2008 May 2.
Published in final edited form as: Nat Genet. 2007 Nov 11;39(12):1507–1511. doi: 10.1038/ng.2007.21

Figure 4.

Figure 4

Permanganate mapping of open transcription bubbles reveals engaged Pol II within the promoter-proximal region of genes with PPEP. In vivo permanganate footprinting demonstrates the presence and locations of engaged Pol II in the promoter-proximal region of five genes with PPEP. Each panel shows a adenine-guanine ladder used for position determination, the reactivity pattern of naked DNA as a control and the permanganate reactivity observed in S2 cells (last lane in each panel). The positions of a subset of hyper-reactive thymine residues are identified to the right of each panel.

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