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. Author manuscript; available in PMC: 2008 May 2.
Published in final edited form as: Cell. 2006 Apr 7;125(1):127–142. doi: 10.1016/j.cell.2006.01.042

Figure 8. Tangential Migration and Axon Guidance in the Central Nervous System.

Figure 8

(A) A model of TCAs guidance by tangential migration of corridor cells and NRG1 expression. GABAergic neurons migrate tangentially from the lateral ganglionic eminence (LGE) to form a corridor in the medial ganglionic eminence (MGE) around E12.5 (blue line) prior to the entrance of TCAs in the telencephalon. At this early stage, the MGE territory is not permissive for TCAs (dark purple area). LGE-derived neurons colonize the MGE mantle around E13.5, forming a permissive corridor for TCAs in this region. CRD-NRG1 expression by corridor cells contributes to the guidance of TCAs through this region, which also requires secreted Ig-NRG1 from the pallium (green gradient). Tangential migration and axon guidance in the developing neural tube.

(B) Radial glia provides structural support for radial migration, a process that results in the generation of different nuclei topographically organized in relation to their place of origin.

(B') Tangential migration is independent of radial glia processes and therefore does not respect topographical references. As a result, tangential migration produces an increase in the cellular complexity of neural circuits by providing cell types distinct from those locally generated and represents a novel mechanism for presenting cues to navigating axons.