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. Author manuscript; available in PMC: 2008 Nov 1.
Published in final edited form as: Am J Physiol Cell Physiol. 2007 Sep 5;293(5):C1586–C1593. doi: 10.1152/ajpcell.00208.2007

Figure 5.

Figure 5

Western blot showing O-linked protein glycosylation in non-transgenic islets cultured for seven days in the presence or absence of 100 μM WAS-406 or 20 μM azaserine. Several O-linked N-acetylglucosamine-modified proteins are detected in islets following seven days of culture in 16.7 mM glucose. In contrast, a decrease in O-linked N-acetylglucosamine-modified proteins was seen following WAS-406 or azaserine treatment, consistent with a down-regulation of flux through the hexosamine biosynthesis pathway (HBP).