Fig. 6.

Human β-defensin 3 (HBD3) also induces both maturation death of human DCs. Human PBL-derived iDCs were treated for 1 day (A) and 3 days (B) with human β-defensin 3 or human β-defensin 1 (20 μg/ml) or with 10 μg/ml mDF2β or saline (conditioned media). Cell death (solid bars) and DC maturation (shaded bars) were assessed as described in Figure 3. Shown are data of a triplicate experiment using individual human donor PBL ± sem. The results were reproduced using DCs from two donors. P values are for comparisons of maturation (A) and survival (B) between two groups as depicted by horizontal lines.