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LPA-induced demyelination of dorsal root fibers in ex vivo culture experiments [74]. The addition of LPA (100 nM) causes demyelination of acutely isolated dorsal root fibers after 12 h, in both scanning and transmission electron microscope (SEM and TEM) analyses. LPA also causes morphological changes in Schwann cells of the Ramaak bundle, which induce close membrane apposition.
