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. 2008 May 14;3(5):e2167. doi: 10.1371/journal.pone.0002167

Figure 4. Different cytological appearances of lesions at the 45S rDNA fragile sites.

Figure 4

A: breakage or constriction occurs to a single chromatid within the 45S rDNA region. B: a gap forms within the rDNA between the two chromosome ends, but is still connected through one or a few thin DNA fibers (local despiralizations of the chromatid). C: A chromosome is broken and completely separated into two parts without any DNA hybridization signals detected within the gap. A1–C1: black layer; A2–C2: color image by merging red layers and green layers. Arrows indicate lesion sites.