Table 2. Electron microscopic examination reveals frequent severely disrupted and larger mitochondria in Y522S fibers.
Column A: The relative percentage of severely disrupted mitochondria in FDB fibers from 2 month old RyR1wt/wt and RyR1Y522S/wt mice. n, total number of mitochondria; Column B: Differences in mitochondria mean diameter in FDB fibers from RyR1wt/wt and RyR1Y522S/wt mice. n, number of measurements. (*p<0.0001). Data are mean ± S.E.M
| Genotype/age | Column A | Column B |
|---|---|---|
| % of severely disrupted mitochondria | Average diameter of mito, nm ± SD | |
| RyR1wt/wt (2–3 months) | 1.1
(n = 1019, 2 mice) |
187 ± 53
(n = 643, 2 mice) |
| RyR1Y522S/wt (2–3 months) | 9.1*
(n = 1493, 4 mice) |
243 ± 72 *
(n = 1069, 4 mice) |