Skip to main content
. Author manuscript; available in PMC: 2008 May 5.
Published in final edited form as: Ann N Y Acad Sci. 2008 Mar;1123:105–112. doi: 10.1196/annals.1420.012

FIGURE 3.

FIGURE 3

Mechanisms contributing to atrial selectivity of ranolazine in depressing Vmax at fast pacing rates: the role of atrial-selective APD prolongations. Shown are action potential tracings and corresponding Vmax values recorded during acceleration of pacing rate from a CL of 500 to 300 ms in atrial and ventricular preparations in the presence of ranolazine. Ranolazine prolongs late repolarization in atria, but not in ventricles. Acceleration of rate leads to elimination of the diastolic interval, resulting in a more positive take-off potential in atrium. The diastolic interval remains relatively long in ventricles. (Modified from Burashnikov et al.2)