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At High Concentration, Genistein Elicits Gene Regulation Very Similar to that by E2
Venn diagrams comparing probe sets regulated by E2 (6 nm) or HG (300 nm) in MCF-7 cells expressing ERα alone or ERα+ERβ. A, Genes regulated at 4 h; B, genes regulated at 24 h; C, volcano plots (log odds vs. fold change) of HG-treated vs. E2-treated samples at 4 h in ERα-only cells (panel 1) or ERα+ERβ cells (panel 2) or at 24 h in ERα-only cells (panel 3) or ERα+ERβ cells (panel 4).
