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. Author manuscript; available in PMC: 2008 May 5.
Published in final edited form as: Chem Res Toxicol. 2006 May;19(5):719–728. doi: 10.1021/tx0600245

Figure 2.

Figure 2

Detection of directly formed AP sites in PAH o-quinone-treated calf thymus DNA under redox-cycling conditions. (A) BP-7,8-dione, (B) 7,12-DMBA-3,4-dione and (C) BA-3,4-dione. See the Materials and methods for details. Kruskal-Wallis tests show that all three quinones had a significant effect on the AP sites generated (p = 0.0094, 0.0367 and 0.0093 for BP-7,8-dione, BA-3,4-dione and 7,12-DMBA-3,4-dione, respectively). Linear regression analysis showed that the concentration of all three quinones had a significant effect on the amount of AP sites (p <0.0001 for all three quinones). In each case, sodium azide blocked the formation of AP sites with p value < 0.0001 at all concentrations of PAH o-quinone tested.