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. 2008 May;19(5):1991–2002. doi: 10.1091/mbc.E06-10-0937

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© 2008 by The American Society for Cell Biology

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Figure 1. — Results of genome-wide synthetic lethality screen of the pik1-101 mutant allele. Genes that have been found in SGA analysis to interact genetically with pik1-101 (synthetic lethal or sick) are represented as nodes. All genetic interactions shown in this scheme have been confirmed by tetrad analysis. Several genetic interactors of CLA4 were found to exhibit synthetic interactions (URM1, ELP2, NCS2, YNL120C, and UBA4). The synthetic genetic interaction with UBA4 was not identified in the genome-wide screen but was found by tetrad analysis in the further course of this study. For a full list of genes isolated in the screen, see Table S1.