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. Author manuscript; available in PMC: 2008 May 5.
Published in final edited form as: J Invest Dermatol. 2007 May 31;127(11):2645–2655. doi: 10.1038/sj.jid.5700890

Figure 1. TNF-α suppresses TGF-β1 induction in human dermal fibroblasts.

Figure 1

Normal human dermal fibroblasts (3 × 105 cells/ml) were seeded in collagen I matrix (1 mg/ml). The fibroblast-populated collagen lattices (FPCLs) were treated with TGF-β1 (1 ng/ml), TNF-α (1 ng/ml), or combinations of TGF-β1 (1 ng/ml) and increasing concentrations of TNF-α for 96 hours under 0.1% serum conditions. Representative Western blots for α-SMA, vimentin, and GAPDH are shown.