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Mutation spectra induced in p53 by PAH o-quinones. The occurrence of point mutations are plotted against codon number for each PAH o-quinone tested under redox cycling conditions. For comparison, spectra of single base substitutions for lung cancer (2,027 singlet mutations) and all cancer excluding lung cancer (16,117 singlet mutations) are shown. Data was extracted from the p53 IARC database R10 release (50).
