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Deletion of PAR2 inhibits TxA-induced enteritis. Images show the ileum. (A) Par2+/+ vehicle control, (B) Par2+/+ TxA, (C) Par2+/− vehicle control, (D) Par2+/− TxA, (E) Par2−/− vehicle control, (F) Par2−/− TxA. Note the normal villous structure in control groups. In Par2+/+ mice, TxA caused pathologic changes including loss of villi, infiltration of granulocytes, and severe necrosis (arrows). Scale bar = 100 μm.
