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Effect of pretreatment with protease inhibitors on TxA-induced pathologic changes. Images show the ileum. (A) Vehicle control, (B) TxA, (C) FUT-175 plus TxA, (D) MPI-0442352 plus TxA, (E) SBTI (10 mg) plus TxA, (F) SBTI (20 mg) plus TxA. TxA caused a marked loss of villi, edema, neutrophil infiltration, and necrosis (arrows). SBTI pretreatment decreased epithelial damage and edema, but neutrophil infiltration was sometimes prominent (arrow). Scale bar = 100 μm.
