Table 3.

Histologic Score for TxA-Induced Enteritis in Mice Pretreated With Protease Inhibitors

Pretreatment + treatment	Epithelial damage	Edema congestion	Polymorphonuclear leukocyte infiltration	Total score
Vehicle + vehicle control	0.44 ± 0.1	0.97 ± 0.1	1.29 ± 0.2	2.73 ± 0.4
Vehicle + TxA	1.61 ± 0.1a	1.77 ± 0.1a	1.90 ± 0.1	5.21 ± 0.2a
FUT-175 + vehicle control	1.02 ± 0.1	0.02 ± 0.1	0.88 ± 0.1	2.65 ± 0.2
FUT-175 + TxA	1.03 ± 0.2a	1.51 ± 0.2	1.77 ± 0.2	4.35 ± 0.3a
MPI-0442352 + vehicle control	0.56 ± 0.1	0.48 ± 0.02	0.56 ± 0.1	1.60 ± 0.2
MPI-0442352 + TxA	1.67 ± 0.2	1.93 ± 0.2	1.98 ± 0.2	5.55 ± 0.5
10 mg SBTI + vehicle control	0.30 ± 0.1	1.30 ± 0.1	1.46 ± 0.1	3.07 ± 0.2
10 mg SBTI + TxA	0.53 ± 0.1b	1.17 ± 0.3b	1.63 ± 0.1	3.32 ± 0.3b
20 mg SBTI + vehicle control	0.43 ± 0.1	0.56 ± 0.1	0.79 ± 0.1	1.87 ± 0.2
20 mg SBTI + TxA	0.86 ± 0.1b	1.06 ± 0.1b	1.24 ± 0.1	3.13 ± 0.3b

NOTE. Vehicle refers to vehicle for protease inhibitors, and vehicle control refers to vehicle for TxA.

^aP < .05 compared with inhibitor vehicle + vehicle control group.

^bP < .05 compared with inhibitor vehicle + TxA group.