. Author manuscript; available in PMC: 2008 May 5.

Published in final edited form as: Cancer Lett. 2006 Oct 9;249(2):148–156. doi: 10.1016/j.canlet.2006.08.008

Table 1.

Effects of genomic and plasmid-borne pms1-E738K mutations on mutation rates in the W303 strain of S. cerevisiae

Genotype (genome)	hom3-10		Genotype(plasmid)^a	hom3-10		CAN1
Genotype (genome)	Mutation rate (×10⁻⁸)	Fold increase	Genotype(plasmid)^a	Mutation rate (×10⁻⁸)^a,^b	Fold increase	Mutation rate (×10⁻⁸)^a,^b	Fold increase
PMS1	1.4	1	Empty vector	0.9 (0.7–1.1)	1	24 (11–37)	1
pms1Δ	873	642	PMS1 (CEN)	1.1 (0.6–1.6)	1.2	30 (23–37)	1.3
pms1-E738K	971	714	pms1-738 (CEN)	1.7 (0.9–2.5)	1.9	36 (18–53)	1.5
			PMS1 (2 μ)	3.3 (1.4–5.2)	3.7	27 (23–30)	1.1
			pms1-738 (2 μ)	213 (165–262)	237	184 (54–314)	7.7

In WT W303 yeast cells.

95% confidence intervals are indicated in parentheses.